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Another category of traf c arises when individual ows and transactions are grouped together in an aggregate traf c stream This occurs currently, for example, when the ow between remotely located LANs must be treated as a traf c entity by a wide area network Proposed evolutions to the Internet service model such as differentiated services and multiprotocol label switching (MPLS) also rely heavily on the notion of traf c aggregation Through aggregation, quality of service requirements are satis ed in a two-step process: the network guarantees that an aggregate has access to a given bandwidth between designated end points; this bandwidth is then shared by ows within the aggregate according to mechanisms like those described in the rest of this chapter.

Although the determination of chemical and physical properties of known or potential toxicants does not constitute a test for toxicity, it is an essential preliminary for such tests. The information obtained can be used in many ways. Structure activity comparisons with other known toxicants may indicate the most probable hazards. These comparisons may also aid identi cation in subsequent poisoning episodes. Determination of stability to light, heat, freezing, and oxidizing or reducing agents may enable preliminary estimates of persistence in the environment as well as indicate the most likely breakdown products that may also require testing for toxicity. Establishing such properties as the lipid solubility or octanol/water partition coef cient may enable preliminary estimates of rate of uptake and persistence in living organisms. Vapor pressure may indicate whether the respiratory system is a probable route of entry. Knowledge of the chemical and physical properties must be acquired in order to develop analytical methods for the measurement of the compound and its degradation products. If the chemical is being produced for commercial use, similar information is needed on intermediates in the synthesis or by-products of the process because both are possible contaminants in the nal product.

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Typically, the network provider has the simple traf c management task of reserving the guaranteed bandwidth while the responsibility for sharing this bandwidth between individual stream and elastic ows devolves to the customer This division of responsibilities alleviates the so-called scalability problem, where the capacity of network elements to maintain state on individual ows cannot keep up with the growth in traf c The situation would be clear if the guarantee provided by the network to the customer were for a xed constant bandwidth throughout a given time interval In practice, because traf c in an aggregation is generally extremely variable (and even self-similar), a constant rate is not usually a good match to user requirements Some burstiness can be accounted for through a leaky bucket based traf c descriptor, although this is not a very satisfactory solution, especially for self-similar traf c (see Section 1632).

Biochemical and genetic evidence for complex formation between the in uenza A virus NS1 protein and the interferon-induced PKR protein kinase J Interferon Cytokine Res 1998, 18(9), 757 766 88 Bergmann, M; Garcia-Sastre, A; Carnero, E; Pehamberger, H; Wolff, K; Palese, P; Muster, T In uenza virus NS1 protein counteracts PKR-mediated inhibition of replication J Virol 2000, 74(13), 6203 6206 89 Hatada, E; Saito, S; Fukuda, R Mutant in uenza viruses with a defective NS1 protein cannot block the activation of PKR in infected cells J Virol 1999 73(3), 2425 2433 90 Wang, X; Li, M; Zheng, H; Muster, T; Palese, P; Beg, A A; Garcia-Sastre, A In uenza A virus NS1 protein prevents activation of NF-kB and induction of a/b interferon J Virol 2000, 74(24), 11566 11573..

Data on exposure and environmental fate are needed, not to determine toxicity, but to provide information that may be useful in the prediction of possible exposure in the event that the chemical is toxic. These tests are primarily useful for chemicals released into the environment such as pesticides, and they include the rate of breakdown under aerobic and anaerobic conditions in soils of various types, the rates of leaching into surface water from soils of various types, and the rate of movement toward groundwater. The effects of physical factors on degradation through photolysis and hydrolysis studies and the identi cation of the product formed can indicate the rate of loss of the hazardous chemical or the possible formation of hazardous degradation products. Tests for accumulation in plants and animals and movement within the ecosystem are considered in Section 21.7.

In existing frame relay and ATM networks, current practice is to considerably overbook capacity (the sum of guaranteed rates may be several times greater than available capacity), counting on the fact that users do not all require their guaranteed bandwidth at the same time This allows a proportionate decrease in the bandwidth charge but, of course, there is no longer any real guarantee In addition, in these networks users are generally allowed to emit traf c at a rate over and above their guaranteed bandwidth This excess traf c, ``tagged'' to designate it as expendable in case of congestion, is handled on a best effort basis using momentarily available capacity Undeniably, the combination of overbooking and tagging leads to a commercial offer that is attractive to many customers.

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